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BLOC project

Benchtop NMR for lab-on a-chip

Organ-on-a-chip (OOC) devices offer new approaches to metabolic disease modelling and drug discovery by providing biologically relevant models of tissues and organs in vitro integrated with sensing technology. As such, OOC devices have the potential to revolutionise the pharmaceutical industry by enabling reliable and high predictive in vitro testing of drug candidates. The capability to miniaturise microfluidic systems and advanced tissue fabrication procedures have enabled researchers to create multiple tissues on a chip with a high degree of control over experimental variables for high-content screening applications.

 

The objective of this project is to develop a new technology based on magnetic resonance spectroscopy and imaging using dynamic nuclear polarisation (DNP-MR) integrated with OOC devices to monitor disease and evaluate drug response in OOC models. As a proof-of-concept, this project will fabricate a biomimetic multi OOC integrated device composed of liver spheroids and pancreatic islets and develop the necessary DNP-MR hardware and software to study metabolic diseases and for future drug screening applications.

Consortium

INSTITUTE FOR BIOENGINEERING OF CATALONIA (IBEC)
 Spain
Carrer BALDIRI REIXAC 10-12
08028 Barcelona

OXFORD INSTRUMENTS
United Kingdom 
TUBNEY WOODS
Abingdon OX13 5QX

 

MULTIWAVE
 Switzerland 
3 CHEMIN DU PRE FLEURI, Geneva 1228

 

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